Title : Calycosin stimulates proliferation of estrogen receptor-positive human breast cancer cells through downregulation of Bax gene expression and upregulation of Bcl-2 gene expression at low concentrations.

Pub. Date : 2011 Nov

PMID : 21799188






2 Functional Relationships(s)
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1 Calycosin stimulates proliferation of estrogen receptor-positive human breast cancer cells through downregulation of Bax gene expression and upregulation of Bcl-2 gene expression at low concentrations. 7,3'-dihydroxy-4'-methoxyisoflavone BCL2 apoptosis regulator Homo sapiens
2 Furthermore, at these concentrations, calycosin decreased the percentage of early apoptosis in MCF-7 cells, downregulated mRNA and protein levels of Bax, and upregulated those of Bcl-2 at low concentrations. 7,3'-dihydroxy-4'-methoxyisoflavone BCL2 apoptosis regulator Homo sapiens