Title : Inhibition of protein-tyrosine phosphatase 1B (PTP1B) mediates ubiquitination and degradation of Bcr-Abl protein.

Pub. Date : 2011 Sep 16

PMID : 21795709






4 Functional Relationships(s)
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1 Inhibition of PTP1B elicits tyrosine phosphorylation of Bcr-Abl that triggers the degradation of Bcr-Abl through ubiquitination via the lysosomal pathway. Tyrosine ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens
2 Inhibition of PTP1B elicits tyrosine phosphorylation of Bcr-Abl that triggers the degradation of Bcr-Abl through ubiquitination via the lysosomal pathway. Tyrosine ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens
3 The degradation of Bcr-Abl consequently inhibits tyrosine phosphorylation of Bcr-Abl substrates and the downstream production of intracellular reactive oxygen species. Tyrosine ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens
4 The degradation of Bcr-Abl consequently inhibits tyrosine phosphorylation of Bcr-Abl substrates and the downstream production of intracellular reactive oxygen species. Tyrosine ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens