Title : Di(2-ethylhexyl)phthalate leached from medical PVC devices serves as a substrate and inhibitor for the P-glycoprotein.

Pub. Date : 2007 May

PMID : 21783769






4 Functional Relationships(s)
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1 The purpose of this study was to investigate the Pgp-reversal activities of phthalates, which are endocrine-disrupting chemicals, by utilizing the Pgp-overexpressing leukemic cell line AML-2/D100. phthalic acid ATP binding cassette subfamily B member 1 Homo sapiens
2 The purpose of this study was to investigate the Pgp-reversal activities of phthalates, which are endocrine-disrupting chemicals, by utilizing the Pgp-overexpressing leukemic cell line AML-2/D100. phthalic acid ATP binding cassette subfamily B member 1 Homo sapiens
3 This is the first report that phthalates can reverse Pgp-mediated MDR by increasing drug accumulation, as well as serving as substrates for the Pgp. phthalic acid ATP binding cassette subfamily B member 1 Homo sapiens
4 This is the first report that phthalates can reverse Pgp-mediated MDR by increasing drug accumulation, as well as serving as substrates for the Pgp. phthalic acid ATP binding cassette subfamily B member 1 Homo sapiens