Pub. Date : 1990 Dec
PMID : 2176946
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Quantitative in situ hybridization histochemistry was used to examine the regulation of aldose reductase messenger RNA in the rat lens after the induction of diabetes mellitus or after feeding a 50% (w/w) galactose diet. | Galactose | aldo-keto reductase family 1 member B1 | Rattus norvegicus |
| 2 | Although increased staining for aldose reductase in the lens epithelium has previously been observed by immunohistochemistry after 3 weeks of diabetes or after 7 days of galactose feeding, we have not been able to detect any increase in the amount of aldose reductase messenger RNA in these cells as compared with controls (113 +/- 7%, 105 +/- 9%, 100 +/- 7%, respectively) at these time points (P greater than 0.05). | Galactose | aldo-keto reductase family 1 member B1 | Rattus norvegicus |
| 3 | After 15 days of galactose feeding, however, there was a significant increase of 140% (+/- 12%) in the amount of aldose reductase messenger RNA in the lens epithelial cells as compared with controls (P = less than 0.001). | Galactose | aldo-keto reductase family 1 member B1 | Rattus norvegicus |
| 4 | These results demonstrate that increased availability of galactose, a high-affinity substrate for the enzyme, leads to increased aldose reductase messenger RNA, which suggests a role for aldose reductase in sugar metabolism in the lens. | Galactose | aldo-keto reductase family 1 member B1 | Rattus norvegicus |
| 5 | These results demonstrate that increased availability of galactose, a high-affinity substrate for the enzyme, leads to increased aldose reductase messenger RNA, which suggests a role for aldose reductase in sugar metabolism in the lens. | Galactose | aldo-keto reductase family 1 member B1 | Rattus norvegicus |