Title : c-Cbl and Cbl-b ligases mediate 17-allylaminodemethoxygeldanamycin-induced degradation of autophosphorylated Flt3 kinase with internal tandem duplication through the ubiquitin proteasome pathway.

Pub. Date : 2011 Sep 2

PMID : 21768087






1 Functional Relationships(s)
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1 Moreover, c-Cbl and Cbl-b facilitated degradation of Flt3-ITD in 293T cells and significantly enhanced the 17-AAG-induced decline in autophosphorylated Flt3-ITD. tanespimycin Cbl proto-oncogene Homo sapiens