Title : Electrophile-modified lipoic derivatives of PDC-E2 elicits anti-mitochondrial antibody reactivity.

Pub. Date : 2011 Nov

PMID : 21763105






1 Functional Relationships(s)
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1 Our results demonstrate that AMA-positive PBC sera demonstrate marked reactivity against 6,8-bis(acetylthio)octanoic acid, implying that chemical modification of the lipoyl ring, i.e. disruption of the S-S disulfide, renders lipoic acid to its reduced form that will promote xenobiotic modification. Thioctic Acid dihydrolipoamide S-acetyltransferase Homo sapiens