Pub. Date : 2011 Jul 16
PMID : 21762526
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Preventive effect of Ibrolipim on suppressing lipid accumulation and increasing lipoprotein lipase in the kidneys of diet-induced diabetic minipigs. | 4-diethoxyphosphorylmethyl-N-(4-bromo-2-cyanophenyl)benzamide | lipoprotein lipase | Homo sapiens |
| 2 | The purpose of this study was to observe the preventive effects of Ibrolipim, a LPL activator, on lipid accumulation and LPL expression in the kidneys of minipigs fed a high-sucrose and high-fat diet (HSFD). | 4-diethoxyphosphorylmethyl-N-(4-bromo-2-cyanophenyl)benzamide | lipoprotein lipase | Homo sapiens |
| 3 | The purpose of this study was to observe the preventive effects of Ibrolipim, a LPL activator, on lipid accumulation and LPL expression in the kidneys of minipigs fed a high-sucrose and high-fat diet (HSFD). | 4-diethoxyphosphorylmethyl-N-(4-bromo-2-cyanophenyl)benzamide | lipoprotein lipase | Homo sapiens |
| 4 | In contrast, supplementing Ibrolipim into HSFD lowered body weight, plasma glucose, insulin, triglyceride and urinary albumin concentrations while it increased plasma total cholesterol and HDL-C. Ibrolipim suppressed the renal accumulation of triglyceride and cholesterol, and stimulated the diet-induced down-regulation of LPL expression and activity in the kidney. | 4-diethoxyphosphorylmethyl-N-(4-bromo-2-cyanophenyl)benzamide | lipoprotein lipase | Homo sapiens |
| 5 | In contrast, supplementing Ibrolipim into HSFD lowered body weight, plasma glucose, insulin, triglyceride and urinary albumin concentrations while it increased plasma total cholesterol and HDL-C. Ibrolipim suppressed the renal accumulation of triglyceride and cholesterol, and stimulated the diet-induced down-regulation of LPL expression and activity in the kidney. | 4-diethoxyphosphorylmethyl-N-(4-bromo-2-cyanophenyl)benzamide | lipoprotein lipase | Homo sapiens |
| 6 | CONCLUSIONS: Ibrolipim exerts renoprotective and hypolipidemic effects via the increase in renal LPL activity and expression, and thus the increased expression and activity of renal LPL play a vital role in suppressing renal lipid accumulation and ameliorating proteinuria in diet-induced diabetic minipigs. | 4-diethoxyphosphorylmethyl-N-(4-bromo-2-cyanophenyl)benzamide | lipoprotein lipase | Homo sapiens |