Title : VLDL hydrolysis by hepatic lipase regulates PPARĪ“ transcriptional responses.

Pub. Date : 2011

PMID : 21750705






1 Functional Relationships(s)
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1 METHODS/PRINCIPAL FINDINGS: Using PPAR ligand binding domain transactivation assays, we found that HL interacted with triglyceride-rich VLDL (>HDL>>LDL, IDL) to activate PPARdelta preferentially over PPARalpha or PPARgamma, an effect dependent on HL catalytic activity. Triglycerides peroxisome proliferator activated receptor alpha Mus musculus