Title : VLDL hydrolysis by hepatic lipase regulates PPARĪ“ transcriptional responses.

Pub. Date : 2011

PMID : 21750705

1 Functional Relationships(s)
Compound Name
Protein Name
1 METHODS/PRINCIPAL FINDINGS: Using PPAR ligand binding domain transactivation assays, we found that HL interacted with triglyceride-rich VLDL (>HDL>>LDL, IDL) to activate PPARdelta preferentially over PPARalpha or PPARgamma, an effect dependent on HL catalytic activity. Triglycerides peroxisome proliferator activated receptor alpha Mus musculus