Title : DARPP-32 increases interactions between epidermal growth factor receptor and ERBB3 to promote tumor resistance to gefitinib.

Pub. Date : 2011 Nov

PMID : 21741919






1 Functional Relationships(s)
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1 DARPP-32-mediated resistance to gefitinib resulted from increased phosphorylation of and interaction between EGFR and ERBB3, which led to phosphorylation of AKT (at serine 473). Serine epidermal growth factor receptor Homo sapiens