Title : Grape seed extract supplementation prevents high-fructose diet-induced insulin resistance in rats by improving insulin and adiponectin signalling pathways.

Pub. Date : 2011 Oct

PMID : 21736810






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1 A high-fructose diet causes insulin resistance by significantly reducing the protein expression of insulin receptor, insulin receptor substrate-1, Akt and GLUT4, and the mRNA expression of adiponectin, adiponectin receptor R1 (AdipoR1) and AMP-activated protein kinase (AMPK)-alpha in the skeletal muscle. Fructose solute carrier family 2 member 4 Rattus norvegicus