Protein Name solute carrier family 2 member 4
Organism Rattus norvegicus
Gene ID 25139
Gene Symbol

Slc2a4

UniProt P19357 (GLUT4_RAT)
Relationships Total Number of functionally related compound(s) : 548
Total Number of Articles : 1045
Description

solute carrier family 2 member 4

Gene Summary

Enables D-glucose transmembrane transporter activity. Involved in several processes, including glucose import in response to insulin stimulus; regulation of synaptic vesicle budding from presynaptic endocytic zone membrane; and response to ethanol. Acts upstream of or within with a positive effect on long-term memory. Acts upstream of or within with a negative effect on short-term memory. Acts upstream of or within learning or memory and positive regulation of brain-derived neurotrophic factor receptor signaling pathway. Located in several cellular components, including T-tubule; clathrin-coated pit; and cytoplasmic vesicle. Is active in presynapse. Colocalizes with vesicle. Biomarker of pulmonary hypertension. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human SLC2A4 (solute carrier family 2 member 4). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • solute carrier family 2, facilitated glucose transporter member 4
  • GLUT-4
  • Glucose transporter 4, insuline-responsive
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Properties