Title : c-Met-Akt pathway-mediated enhancement of inhibitory c-Raf phosphorylation is involved in vitamin K1 and sorafenib synergy on HCC growth inhibition.

Pub. Date : 2011 Sep 15

PMID : 21734462






1 Functional Relationships(s)
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1 However, vitamin K1 enhanced sorafenib-induced c-Met phosphorylation at Tyr-1349, a DEP-1 protein phosphatase acting site, and consequently induced phosphorylation of PI3K-Akt. Tyrosine MET proto-oncogene, receptor tyrosine kinase Homo sapiens