Pub. Date : 2011 Sep 5
PMID : 21721129
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Because kinase inhibitors that target the inactive conformation are thought to be more specific than ATP-targeted inhibitors, we investigated the possibility of using two known inhibitors, doramapimod and sorafenib, which target inactive kinases, to design new urea derivatives as ALK inhibitors. | Sorafenib | ALK receptor tyrosine kinase | Homo sapiens |
| 2 | We generated a homology model of ALK in its inactive conformation complexed with doramapimod or sorafenib in its active site. | Sorafenib | ALK receptor tyrosine kinase | Homo sapiens |