Pub. Date : 2011
PMID : 21720550
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Talin overexpression was sufficient to trigger NF-kB activity following treatment with cisplatin in carcinoma matrix adherent HN12 cells in a process disrupted by FAK siRNA. | Cisplatin | protein tyrosine kinase 2 | Homo sapiens |
| 2 | Thus, adhesions within the carcinoma matrix create a matrix environment in which exposure to cisplatin induces proliferation through the function of integrin beta1, talin and FAK pathways that regulate NF-kB nuclear activity. | Cisplatin | protein tyrosine kinase 2 | Homo sapiens |