Pub. Date : 2011 Sep
PMID : 21719246
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cytotoxicity of paclitaxel in OVCAR-3, SK-OV-3 and OATP1B1- and OATP1B3-transfected SK-OV-3 cells was performed using the CellTiter-Glo assay. | Paclitaxel | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 2 | The higher mRNA levels for OATP1B1 and OATP1B3 found in SK-OV-3 cells correlated with higher initial uptake rates for paclitaxel. | Paclitaxel | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 3 | CONCLUSIONS: Our results revealed OATP1B1 and OATP1B3 as high-affinity paclitaxel transporters expressed in ovarian cancer cell lines and tumor tissues, suggesting a role for these polypeptides in the disposition of paclitaxel during therapy. | Paclitaxel | solute carrier organic anion transporter family member 1B1 | Homo sapiens |