Title : Pseudohypophosphatasia: aberrant localization and substrate specificity of alkaline phosphatase in cultured skin fibroblasts.

Pub. Date : 1990 Nov

PMID : 2171330






1 Functional Relationships(s)
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1 Despite substantial ALP activity, in cell homogenates, toward the artificial substrate 4-methyl-umbelliferyl phosphate (4-MUP), there was a marked deficiency in ALP activity toward the natural substrates pyridoxal 5"-phosphate (PLP) and phosphoethanolamine (PEA), indicating altered substrate specificity. Pyridoxal Phosphate alkaline phosphatase, placental Homo sapiens