Pub. Date : 2011 Oct
PMID : 21699843
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Protein kinase C downregulates I(Ks) by stimulating KCNQ1-KCNE1 potassium channel endocytosis. | Potassium | potassium voltage-gated channel subfamily E member 1 | Cricetulus griseus |
| 2 | BACKGROUND: The slow-activating cardiac repolarization K(+) current (I(Ks)), generated by the KCNQ1-KCNE1 potassium channel complex, is controlled via sympathetic and parasympathetic regulation in vivo. | Potassium | potassium voltage-gated channel subfamily E member 1 | Cricetulus griseus |
| 3 | Protein kinase C (PKC), which is activated by alpha1 adrenergic receptor stimulation, is known to downregulate I(Ks) via phosphorylation of KCNE1 serine 102, but the underlying mechanism has remained enigmatic. | Potassium | potassium voltage-gated channel subfamily E member 1 | Cricetulus griseus |
| 4 | KCNE1-S102A abolished the effect of PMA on I(Ks) currents and endocytosis. | Potassium | potassium voltage-gated channel subfamily E member 1 | Cricetulus griseus |