PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21699843-0 2011 Protein kinase C downregulates I(Ks) by stimulating KCNQ1-KCNE1 potassium channel endocytosis. Potassium 33-35 potassium voltage-gated channel subfamily E member 1 Cricetulus griseus 58-63 21699843-1 2011 BACKGROUND: The slow-activating cardiac repolarization K(+) current (I(Ks)), generated by the KCNQ1-KCNE1 potassium channel complex, is controlled via sympathetic and parasympathetic regulation in vivo. Potassium 71-73 potassium voltage-gated channel subfamily E member 1 Cricetulus griseus 100-105 21699843-3 2011 Protein kinase C (PKC), which is activated by alpha1 adrenergic receptor stimulation, is known to downregulate I(Ks) via phosphorylation of KCNE1 serine 102, but the underlying mechanism has remained enigmatic. Potassium 113-115 potassium voltage-gated channel subfamily E member 1 Cricetulus griseus 140-145 21699843-10 2011 KCNE1-S102A abolished the effect of PMA on I(Ks) currents and endocytosis. Potassium 45-47 potassium voltage-gated channel subfamily E member 1 Cricetulus griseus 0-5