Title : Indirubins decrease glioma invasion by blocking migratory phenotypes in both the tumor and stromal endothelial cell compartments.

Pub. Date : 2011 Aug 15

PMID : 21697283






1 Functional Relationships(s)
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1 In addition, indirubins blocked migration of endothelial cells, suggesting that anti-invasive glioma therapy with GSK-3 inhibitors in vivo not only inhibits invasion of tumor cells, but blocks migration of endothelial cells, which is also required for tumor angiogenesis. indirubin glycogen synthase kinase 3 beta Mus musculus