Title : Mild hypoglycaemic attacks induced by sulphonylureas related to CYP2C9, CYP2C19 and CYP2C8 polymorphisms in routine clinical setting.

Pub. Date : 2011 Dec

PMID : 21691805






2 Functional Relationships(s)
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1 However, only in the gliclazide group a significant association between CYP2C9 genotype and hypoglycaemic attacks was observed (P = 0.035). Gliclazide cytochrome P450 family 2 subfamily C member 9 Homo sapiens
2 CONCLUSIONS: CYP2C9 polymorphisms leading to decreased enzyme activity show a modest impact on the risk of mild hypoglycaemia attacks during oral antidiabetic treatment, with a significant association in patients treated with gliclazide. Gliclazide cytochrome P450 family 2 subfamily C member 9 Homo sapiens