Title : Towards Al-induced manganese-containing superoxide dismutase inactivation and conformational changes: an integrating study with docking simulations.

Pub. Date : 2011

PMID : 21687640






6 Functional Relationships(s)
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1 We studied the inhibitory effects of Al(3+) on the activity and conformation of manganese-containing SOD (Mn-SOD). ALUMINUM ION superoxide dismutase 2 Homo sapiens
2 Mn-SOD was significantly inactivated by Al(3+) in a dose-dependent manner. ALUMINUM ION superoxide dismutase 2 Homo sapiens
3 The kinetic studies showed that Al(3+) inactivated Mn-SOD follows the first-order reaction. ALUMINUM ION superoxide dismutase 2 Homo sapiens
4 Al(3+) increased the degree of secondary structure of Mn-SOD and also disrupted the tertiary structure of Mn-SOD, which directly resulted in enzyme inactivation. ALUMINUM ION superoxide dismutase 2 Homo sapiens
5 Al(3+) increased the degree of secondary structure of Mn-SOD and also disrupted the tertiary structure of Mn-SOD, which directly resulted in enzyme inactivation. ALUMINUM ION superoxide dismutase 2 Homo sapiens
6 Our results provide insight into the inactivation of Mn-SOD during unfolding in the presence of Al(3+) and allow us to describe a ligand binding via inhibition kinetics combined with the computational prediction. ALUMINUM ION superoxide dismutase 2 Homo sapiens