Pub. Date : 2011
PMID : 21687640
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | We studied the inhibitory effects of Al(3+) on the activity and conformation of manganese-containing SOD (Mn-SOD). | ALUMINUM ION | superoxide dismutase 2 | Homo sapiens |
2 | Mn-SOD was significantly inactivated by Al(3+) in a dose-dependent manner. | ALUMINUM ION | superoxide dismutase 2 | Homo sapiens |
3 | The kinetic studies showed that Al(3+) inactivated Mn-SOD follows the first-order reaction. | ALUMINUM ION | superoxide dismutase 2 | Homo sapiens |
4 | Al(3+) increased the degree of secondary structure of Mn-SOD and also disrupted the tertiary structure of Mn-SOD, which directly resulted in enzyme inactivation. | ALUMINUM ION | superoxide dismutase 2 | Homo sapiens |
5 | Al(3+) increased the degree of secondary structure of Mn-SOD and also disrupted the tertiary structure of Mn-SOD, which directly resulted in enzyme inactivation. | ALUMINUM ION | superoxide dismutase 2 | Homo sapiens |
6 | Our results provide insight into the inactivation of Mn-SOD during unfolding in the presence of Al(3+) and allow us to describe a ligand binding via inhibition kinetics combined with the computational prediction. | ALUMINUM ION | superoxide dismutase 2 | Homo sapiens |