Title : Controlling the aggregation and rate of release in order to improve insulin formulation: molecular dynamics study of full-length insulin amyloid oligomer models.

Pub. Date : 2012 Mar

PMID : 21674205

1 Functional Relationships(s)
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1 Here we report on a molecular dynamics (MD) study of single-layer oligomers of the full-length insulin which aimed to identify the structural elements that are important for amyloid stability, and to suggest single glycine mutants in the beta-sheet region that may improve the formulation. Glycine insulin Homo sapiens