Pub. Date : 1990 Jul
PMID : 2167226
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dibutyryl cyclic AMP, which is a cAMP analog able to penetrate into the cytosol, increased lymphocyte binding to the same extent as IL 1. | Cyclic AMP | interleukin 1 alpha | Homo sapiens |
| 2 | IL 1 increased the level of cytosolic cAMP in a time- and dose-dependent manner measured with radioimmunoassay. | Cyclic AMP | interleukin 1 alpha | Homo sapiens |
| 3 | 2",5"-Dideoxyadenosine, which is an inhibitor of adenylate cyclase, decreased both the IL 1-induced lymphocyte binding to endothelial cells and elevation in cytosolic cAMP levels. | Cyclic AMP | interleukin 1 alpha | Homo sapiens |
| 4 | Lymphocyte binding increased with cytosolic cAMP levels in accordance with elevation of IL 1 concentration. | Cyclic AMP | interleukin 1 alpha | Homo sapiens |
| 5 | These results suggest that cAMP is essential in signal transduction during IL 1-induced lymphocyte binding to cultured endothelial cell monolayers. | Cyclic AMP | interleukin 1 alpha | Homo sapiens |