Pub. Date : 2011 Jul
PMID : 21664964
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | UNLABELLED: The methoxychlor metabolite, HPTE, was shown to inhibit P450-cholesterol side-chain cleavage (P450scc) activity resulting in decreased progesterone production by cultured ovarian follicular cells in previous studies. | Progesterone | cytochrome P450, family 11, subfamily a, polypeptide 1 | Rattus norvegicus |
| 2 | UNLABELLED: The methoxychlor metabolite, HPTE, was shown to inhibit P450-cholesterol side-chain cleavage (P450scc) activity resulting in decreased progesterone production by cultured ovarian follicular cells in previous studies. | Progesterone | cytochrome P450, family 11, subfamily a, polypeptide 1 | Rattus norvegicus |
| 3 | These results suggest that HPTE directly inhibits P450scc catalytic activity resulting in reduced progesterone formation, and this action was not mediated through estrogen or androgen receptors. | Progesterone | cytochrome P450, family 11, subfamily a, polypeptide 1 | Rattus norvegicus |