Title : CD4+CD25+Foxp3+IFN-γ+ human induced T regulatory cells are induced by interferon-γ and suppress alloresponses nonspecifically.

Pub. Date : 2011 Sep

PMID : 21664396






3 Functional Relationships(s)
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1 Herein, the in vitro function of separated CD3(+)CD4(+)CD25(+)Foxp3(+)IFN-gamma(+) PBL that were induced by phorbol 12-myristate 13-acetate (PMA)/ionomycin or alloantigenic stimulation was investigated using cell coculture techniques and flow cytometry. Ionomycin CD4 molecule Homo sapiens
2 CD4(+)CD25(+)Foxp3(+) PBL with intracellular IFN-gamma production increased to 26% in cell cultures stimulated with PMA/ionomycin for 6 hours. Ionomycin CD4 molecule Homo sapiens
3 Addition of enriched CD4(+)CD25(+)IFN-gamma(+) PBL to autologous PMA/ionomycin stimulated PBL decreased blast formation (p < 0.05), indicating suppression of cell proliferation by CD4(+)CD25(+)IFN-gamma(+) PBL. Ionomycin CD4 molecule Homo sapiens