Title : Epigallocatechin-3-gallate prevents lupus nephritis development in mice via enhancing the Nrf2 antioxidant pathway and inhibiting NLRP3 inflammasome activation.

Pub. Date : 2011 Aug 1

PMID : 21641991






4 Functional Relationships(s)
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1 Although epigallocatechin-3-gallate (EGCG), the major bioactive polyphenol present in green tea with antioxidant and free radical scavenging activities, has been reported to have anti-inflammatory effects by inhibiting nuclear factor-kappa B (NF-kappaB)-mediated inflammatory responses in vivo, its effectiveness for the treatment of lupus nephritis is still unknown. epigallocatechin gallate nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus
2 Although epigallocatechin-3-gallate (EGCG), the major bioactive polyphenol present in green tea with antioxidant and free radical scavenging activities, has been reported to have anti-inflammatory effects by inhibiting nuclear factor-kappa B (NF-kappaB)-mediated inflammatory responses in vivo, its effectiveness for the treatment of lupus nephritis is still unknown. epigallocatechin gallate nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus
3 Although epigallocatechin-3-gallate (EGCG), the major bioactive polyphenol present in green tea with antioxidant and free radical scavenging activities, has been reported to have anti-inflammatory effects by inhibiting nuclear factor-kappa B (NF-kappaB)-mediated inflammatory responses in vivo, its effectiveness for the treatment of lupus nephritis is still unknown. epigallocatechin gallate nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus
4 Although epigallocatechin-3-gallate (EGCG), the major bioactive polyphenol present in green tea with antioxidant and free radical scavenging activities, has been reported to have anti-inflammatory effects by inhibiting nuclear factor-kappa B (NF-kappaB)-mediated inflammatory responses in vivo, its effectiveness for the treatment of lupus nephritis is still unknown. epigallocatechin gallate nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus