Pub. Date : 2011 Jul 13
PMID : 21630638
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Hispolon induces apoptosis and cell cycle arrest of human hepatocellular carcinoma Hep3B cells by modulating ERK phosphorylation. | hispolon | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | Inhibitors of ERK (PB98095), but not those of JNK (SP600125) and p38 MAPK (SB203580), suppressed hispolon-induced S-phase arrest and apoptosis in Hep3B cells. | hispolon | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | These findings establish a mechanistic link between the MAPK pathway and hispolon-induced cell cycle arrest and apoptosis in Hep3B cells. | hispolon | mitogen-activated protein kinase 1 | Homo sapiens |