Title : The uptake transporter OATP8 expression decreases during multistep hepatocarcinogenesis: correlation with gadoxetic acid enhanced MR imaging.

Pub. Date : 2011 Oct

PMID : 21626360






3 Functional Relationships(s)
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1 The uptake transporter OATP8 expression decreases during multistep hepatocarcinogenesis: correlation with gadoxetic acid enhanced MR imaging. gadolinium ethoxybenzyl DTPA solute carrier organic anion transporter family member 1B3 Homo sapiens
2 OBJECTIVES: To clarify the changes in organic anion-transporting polypeptide 8 (OATP8) expression and enhancement ratio on gadoxetic acid-enhanced MR imaging in hepatocellular nodules during multistep hepatocarcinogenesis. gadolinium ethoxybenzyl DTPA solute carrier organic anion transporter family member 1B3 Homo sapiens
3 CONCLUSIONS: The immunohistochemical expression of OATP8 significantly decreases during multistep hepatocarcinogenesis, which may explain the decrease in enhancement ratio on gadoxetic acid-enhanced MR imaging. gadolinium ethoxybenzyl DTPA solute carrier organic anion transporter family member 1B3 Homo sapiens