Title : The interplay between NF-kappaB and E2F1 coordinately regulates inflammation and metabolism in human cardiac cells.

Pub. Date : 2011

PMID : 21625432






2 Functional Relationships(s)
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1 However, addition of the NF-kappaB inhibitor parthenolide to these cells prevents the downregulation of PDK4 expression but not ERRalpha and PPARbeta/delta DNA binding activity, thus suggesting that additional transcription factors are regulating PDK4. parthenolide nuclear factor kappa B subunit 1 Homo sapiens
2 Interestingly, the NF-kappaB inhibitor parthenolide prevented the inhibition of E2F1, while E2F1 overexpression reduced interleukin expression in stimulated cardiac cells. parthenolide nuclear factor kappa B subunit 1 Homo sapiens