Pub. Date : 2011 Aug
PMID : 21613233
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of renal NQO1 activity by dicoumarol suppresses nitroreduction of aristolochic acid I and attenuates its nephrotoxicity. | Dicumarol | NAD(P)H dehydrogenase, quinone 1 | Mus musculus |
| 2 | Inhibition of NQO1 activity by dicoumarol pretreatment significantly decreased renal aristolactam I (ALI) levels, a major reductive metabolite of AAI, whereas it increased renal AAI and its major oxidative metabolite 8-hydroxy-aristolochic acid I (AAIa) levels in male C57BL/6 mice. | Dicumarol | NAD(P)H dehydrogenase, quinone 1 | Mus musculus |