Title : Inhibition of the mTOR/p70S6K pathway is not involved in the insulin-sensitizing effect of AMPK on cardiac glucose uptake.

Pub. Date : 2011 Aug

PMID : 21602475






1 Functional Relationships(s)
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1 Mimicking AMPK activators in the presence of insulin, rapamycin inhibited p70S6K and reduced IRS-1 phosphorylation on serine, resulting in the overphosphorylation of PKB/Akt and AS160. Sirolimus protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens