Title : Exploring QSARs for 5-lipoxygenase (5-LO) inhibitory activity of 2-substituted 5-hydroxyindole-3-carboxylates by CoMFA and CoMSIA.

Pub. Date : 2011 Aug

PMID : 21599857






1 Functional Relationships(s)
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1 A series of indole and related benzo[g]indole compounds displaying potent activities against 5-lipoxygenase were selected to establish three-dimensional quantitative structure-activity relationships using comparative molecular field analysis and comparative molecular similarity indices analysis methods. indole arachidonate 5-lipoxygenase Homo sapiens