Pub. Date : 2012 Aug
PMID : 21586598
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The aim of this study was to develop biodegradable, tetracycline-loaded microparticles made of two polymers: PLGA and zein which were compressed into monolithic devices. | Tetracycline | zein | Zea mays |
| 2 | The interaction of tetracycline with the corn protein zein was studied by nuclear magnetic resonance (NMR), Fourier transform infrared, and X-ray diffraction. | Tetracycline | zein | Zea mays |
| 3 | The hydrophobic interaction of tetracycline with zein in the formulations was deduced from the NMR studies, whereas X-ray diffraction studies showed a new crystalline state of the drug in the presence of the protein. | Tetracycline | zein | Zea mays |
| 4 | Sustained release of tetracycline was obtained, and the proportion of zein in the inserts had a great impact on the drug release. | Tetracycline | zein | Zea mays |
| 5 | In conclusion, the PLGA:zein delivery system described in this study was found to be effective in controlled delivery of tetracycline, and hence may be suitable for intra-pocket delivery of antimicrobial agents in the treatment of periodontitis. | Tetracycline | zein | Zea mays |