Pub. Date : 2011 Jun 20
PMID : 21570986
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Interleukin-6 plays a protective role in development of cisplatin-induced acute renal failure through upregulation of anti-oxidative stress factors. | Cisplatin | interleukin 6 | Mus musculus |
| 2 | We previously reported that cisplatin induced more severe renal dysfunction in interleukin-6 (IL-6) knockout (IL-6(-/-)) mice than in wild-type (WT) mice. | Cisplatin | interleukin 6 | Mus musculus |
| 3 | We previously reported that cisplatin induced more severe renal dysfunction in interleukin-6 (IL-6) knockout (IL-6(-/-)) mice than in wild-type (WT) mice. | Cisplatin | interleukin 6 | Mus musculus |
| 4 | We previously reported that cisplatin induced more severe renal dysfunction in interleukin-6 (IL-6) knockout (IL-6(-/-)) mice than in wild-type (WT) mice. | Cisplatin | interleukin 6 | Mus musculus |
| 5 | Expression of a pro-apoptotic protein was significantly increased with cisplatin in IL-6(-/-) mice compared to that in WT mice. | Cisplatin | interleukin 6 | Mus musculus |
| 6 | IL-6, locally expressed in renal tubular cells after cisplatin administration, prevents the development of renal dysfunction at an early stage. | Cisplatin | interleukin 6 | Mus musculus |
| 7 | In the present study, we focused on downstream signals of IL-6 and oxidative stress induced by cisplatin in order to evaluate the protective role of IL-6 in the development of acute renal failure. | Cisplatin | interleukin 6 | Mus musculus |
| 8 | KEY FINDINGS: Cisplatin increased the expression of 4-HNE and cox-2, and phosphorylation of ERK in IL-6(-/-) mice than in WT mice. | Cisplatin | interleukin 6 | Mus musculus |
| 9 | On the other hand, activity of superoxide dismutase, an anti-oxidative enzyme, was significantly decreased in the kidney obtained from IL-6(-/-) mice after cisplatin administration. | Cisplatin | interleukin 6 | Mus musculus |
| 10 | SIGNIFICANCE: Our findings suggest that IL-6 plays a protective role in the development of cisplatin-induced acute renal failure through upregulation of anti-oxidative stress factors. | Cisplatin | interleukin 6 | Mus musculus |