Pub. Date : 2011 Jun
PMID : 21562974
4 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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| 1 | LV-IS-reduction induced by esmolol + milrinone was eliminated in the presence of protein kinase A-(PKA)-inhibitor (Rp-cAMPS) or Akt-inhibitor (AKT 1/2 kinase inhibitor). | Milrinone | AKT serine/threonine kinase 1 | Rattus norvegicus | ||
| 2 | LV-IS-reduction induced by esmolol + milrinone was eliminated in the presence of protein kinase A-(PKA)-inhibitor (Rp-cAMPS) or Akt-inhibitor (AKT 1/2 kinase inhibitor). | Milrinone | AKT serine/threonine kinase 1 | Rattus norvegicus | ||
| 3 | This cell protective effect by esmolol + milrinone was abrogated in the presence of PKA-inhibitor or Akt-inhibitor. | Milrinone | AKT serine/threonine kinase 1 | Rattus norvegicus | ||
| 4 | CONCLUSIONS: Late-ischemia/early reperfusion therapy with esmolol + milrinone additively reduces LV-IS associated with robust activation of myocardial PKA and subsequent Akt-antiapoptotic pathway. | Milrinone | AKT serine/threonine kinase 1 | Rattus norvegicus | ||