Title : Sensitivity of intravenous and oral alfentanil and pupillary miosis as minimal and noninvasive probes for hepatic and first-pass CYP3A induction.

Pub. Date : 2011 Jul

PMID : 21562488






3 Functional Relationships(s)
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1 Systemic and oral clearances of alfentanil (ALF) are in vivo probes for hepatic and first-pass cytochrome P450 (CYP) 3A. Alfentanil cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 Systemic and oral clearances of alfentanil (ALF) are in vivo probes for hepatic and first-pass cytochrome P450 (CYP) 3A. Alfentanil cytochrome P450 family 3 subfamily A member 4 Homo sapiens
3 This investigation determined ALF sensitivity for detecting graded CYP3A induction and compared it with that of midazolam (MDZ). Alfentanil cytochrome P450 family 3 subfamily A member 4 Homo sapiens