Title : Factors regulating amino acid release from extrasplanchnic tissues in the rat. Interactions of alanine and glutamine.

Pub. Date : 1975 Sep

PMID : 2155






2 Functional Relationships(s)
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1 It was concluded that: (a) the alanine aminotransferase and the glutamine synthetase pathways respectively were responsible for 80% of the alanine and glutamine released into the circulation by the extrasplanchnic tissues, and extrahepatic proteolysis could account for a maximum of 20%; (b) alanine formation by the peripheral tissues was dependent on availability of pyruvate and not of glutamate; (c) glutamate availability could influence glutamine formation subject, possibly, to renal control. Glutamic Acid glutamate-ammonia ligase Rattus norvegicus
2 It was concluded that: (a) the alanine aminotransferase and the glutamine synthetase pathways respectively were responsible for 80% of the alanine and glutamine released into the circulation by the extrasplanchnic tissues, and extrahepatic proteolysis could account for a maximum of 20%; (b) alanine formation by the peripheral tissues was dependent on availability of pyruvate and not of glutamate; (c) glutamate availability could influence glutamine formation subject, possibly, to renal control. Glutamic Acid glutamate-ammonia ligase Rattus norvegicus