Title : Increased efflux of oxidized glutathione (GSSG) causes glutathione depletion and potentially diminishes antioxidant defense in sickle erythrocytes.

Pub. Date : 2011 Nov

PMID : 21558001






1 Functional Relationships(s)
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1 GSSG efflux, mediated by multidrug resistance-associated protein-1, is increased in sickle erythrocytes, resulting in net loss of intracellular glutathione and possibly higher susceptibility to oxidative stress. Glutathione ATP binding cassette subfamily C member 1 Homo sapiens