Pub. Date : 2011 Nov
PMID : 21547417
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we found that exposure of the dopaminergic neuroblastoma SHSY-5Y cells to 1-10 muM idebenone for 72 h had no effect on the cell viability revealed by trypan blue exclusion assay and MTT assay. | idebenone | latexin | Homo sapiens |
| 2 | However, cells exposed to 25 muM or higher concentrations of idebenone showed extensive trypan blue-positive staining and significant reduction in cell viability revealed by MTT assay indicating that most of the cells were no longer viable. | idebenone | latexin | Homo sapiens |
| 3 | In addition, idebenone induced an increase in the total RNA of the pro-apoptosis protein BAX, it also increased the caspase-3 activity in the cell lysates when compared with the untreated control cells or cells exposed to 10 muM or lower concentrations of idebenone. | idebenone | latexin | Homo sapiens |