PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21547417-4 2011 In this study, we found that exposure of the dopaminergic neuroblastoma SHSY-5Y cells to 1-10 muM idebenone for 72 h had no effect on the cell viability revealed by trypan blue exclusion assay and MTT assay. idebenone 98-107 latexin Homo sapiens 94-97 21547417-5 2011 However, cells exposed to 25 muM or higher concentrations of idebenone showed extensive trypan blue-positive staining and significant reduction in cell viability revealed by MTT assay indicating that most of the cells were no longer viable. idebenone 61-70 latexin Homo sapiens 29-32 21547417-7 2011 In addition, idebenone induced an increase in the total RNA of the pro-apoptosis protein BAX, it also increased the caspase-3 activity in the cell lysates when compared with the untreated control cells or cells exposed to 10 muM or lower concentrations of idebenone. idebenone 13-22 latexin Homo sapiens 225-228