Pub. Date : 1996 Sep
PMID : 21541537
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dysregulation of transforming growth factor-beta 1 expression in N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis. | nitrosobenzylmethylamine | transforming growth factor, beta 1 | Rattus norvegicus |
| 2 | To further investigate the role of TGF-beta 1 in chemically-induced esophageal tumorigenesis, the expression of TGF-beta 1 was analyzed by reverse transcription-polymerase chain reaction (T-PCR) and immunohistochemical studies in N-nitrosomethylbenzylamine (NMBA)-induced rat esophageal tumorigenesis. | nitrosobenzylmethylamine | transforming growth factor, beta 1 | Rattus norvegicus |
| 3 | However, TGF-beta 1 mRNA levels were increased 2.9-fold (p<0.05) in 45-week papillomas induced by NMBA, when compared to normal rat esophageal epithelium. | nitrosobenzylmethylamine | transforming growth factor, beta 1 | Rattus norvegicus |
| 4 | These findings suggest that overexpression of TGF-beta 1 mRNA occurs late in NMBA-induced rat esophageal tumorigenesis, and the discordant mRNA and protein expression may result in tumor evasion from TGF-beta 1 controlled negative growth regulation, thus promoting tumor progression in this model. | nitrosobenzylmethylamine | transforming growth factor, beta 1 | Rattus norvegicus |