Title : Delineation of an enhancerlike positive regulatory element in the interleukin-2 receptor alpha-chain gene.

Pub. Date : 1990 Feb

PMID : 2153927






2 Functional Relationships(s)
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1 We have delineated a positive regulatory element in the interleukin-2 receptor alpha-chain gene (IL-2R alpha) between positions -299 and -243 that can potently activate a heterologous (herpesvirus thymidine kinase [tk]) promoter in phorbol myristate acetate (PMA)-induced Jurkat T cells and is functional when cloned in either orientation. Tetradecanoylphorbol Acetate interleukin 2 receptor subunit alpha Homo sapiens
2 We have delineated a positive regulatory element in the interleukin-2 receptor alpha-chain gene (IL-2R alpha) between positions -299 and -243 that can potently activate a heterologous (herpesvirus thymidine kinase [tk]) promoter in phorbol myristate acetate (PMA)-induced Jurkat T cells and is functional when cloned in either orientation. Tetradecanoylphorbol Acetate interleukin 2 receptor subunit alpha Homo sapiens