Protein Name interleukin 2 receptor subunit alpha
Organism Homo sapiens
Gene ID 3559
Gene Symbol

IL2RA

UniProt P01589 (IL2RA_HUMAN), Q5W005 (Q5W005_HUMAN)
Relationships Total Number of functionally related compound(s) : 705
Total Number of Articles : 1128
Description

interleukin 2 receptor subunit alpha

Gene Summary

The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. Patients with severe Coronavirus Disease 2019 (COVID-19), the disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have significantly elevated levels of IL2R in their plasma. Similarly, serum IL-2R levels are found to be elevated in patients with different types of carcinomas. Certain IL2RA and IL2RB gene polymorphisms have been associated with lung cancer risk. [provided by RefSeq, Jul 2020]

synonyms
  • interleukin-2 receptor subunit alpha
  • IL-2 receptor subunit alpha
  • IL-2R subunit alpha
Click to show/hide the synonyms
Properties