Pub. Date : 2011
PMID : 21528155
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | All-trans retinoic acid upregulates reduced CD38 transcription in lymphoblastoid cell lines from Autism spectrum disorder. | Tretinoin | CD38 molecule | Homo sapiens |
| 2 | One of these, all-trans retinoic acid (ATRA), a known inducer of CD38, was added during cell culture and tested on a large sample of N = 120 lymphoblastoid cell (LBC) lines from ASD patients and their parents. | Tretinoin | CD38 molecule | Homo sapiens |
| 3 | One of these, all-trans retinoic acid (ATRA), a known inducer of CD38, was added during cell culture and tested on a large sample of N = 120 lymphoblastoid cell (LBC) lines from ASD patients and their parents. | Tretinoin | CD38 molecule | Homo sapiens |
| 4 | Analysis of CD38 mRNA levels shows that ATRA has an upmodulatory potential on LBC derived from ASD patients as well as from their parents. | Tretinoin | CD38 molecule | Homo sapiens |
| 5 | In addition, analysis of the role of genetic polymorphisms in the dynamics of the molecule revealed that the genotype of a single-nucleotide polymorphism (rs6449182; C>G variation) in the CpG island of intron 1, harboring the retinoic-acid response element, exerts differential roles in CD38 expression in ASD and in parental LBC. | Tretinoin | CD38 molecule | Homo sapiens |