Pub. Date : 2011 Jul
PMID : 21527745
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | SUMO1 negatively regulates reactive oxygen species production from NADPH oxidases. | Reactive Oxygen Species | small ubiquitin like modifier 1 | Homo sapiens |
| 2 | In contrast, inhibition of endogenous SUMOylation with small interfering RNA to SUMO1 or ubiquitin conjugating enzyme 9 or with the inhibitor anacardic acid increased ROS production from human embryonic kidney-Nox5 cells, human vascular smooth muscle cells, and neutrophils. | Reactive Oxygen Species | small ubiquitin like modifier 1 | Homo sapiens |
| 3 | The suppression of ROS production was unique to SUMO1, and it required a C-terminal diglycine and the SUMO-specific conjugating enzyme ubiquitin conjugating enzyme 9. | Reactive Oxygen Species | small ubiquitin like modifier 1 | Homo sapiens |
| 4 | SUMO1 did not modify intracellular calcium or Nox5 phosphorylation but reduced ROS output in an isolated enzyme assay, suggesting direct effects of SUMOylation on enzyme activity. | Reactive Oxygen Species | small ubiquitin like modifier 1 | Homo sapiens |