Title : Thyrotropin receptor stimulates internalization-independent persistent phosphoinositide signaling.

Pub. Date : 2011 Aug

PMID : 21525174






2 Functional Relationships(s)
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1 The thyrotropin [thyroid-stimulating hormone (TSH)] receptor (TSHR) is known to acutely and persistently stimulate cAMP signaling and at higher TSH concentrations to acutely stimulate phosphoinositide signaling. Thyrotropin thyroid stimulating hormone receptor Homo sapiens
2 We measured persistent signaling by stimulating TSHR-expressing human embryonic kidney-EM293 cells with TSH and measuring cAMP or inositol monophosphate (IP1) production, a measure of phosphoinositide signaling, 60 min or longer after TSH removal. Thyrotropin thyroid stimulating hormone receptor Homo sapiens