Pub. Date : 2011 Jul
PMID : 21519916
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Concomitantly, the co-treatment of cryptotanshinone and TNF-alpha elicited apoptosis, manifested by enhanced the number of terminal deoxynucleotide transferase-mediated dUTP-nick-end labeling (TUNEL)-positive cells, the sub-G1 cell populations, and the activation of caspase-8 and -3, in comparison with the treatment with either drug alone. | cryptotanshinone | caspase 8 | Homo sapiens |
| 2 | The treatment with cryptotanshinone further suppressed TNF-alpha-mediated expression of c-FLIP(L), Bcl-x(L), but the increased level of tBid (a caspase-8 substrate). | cryptotanshinone | caspase 8 | Homo sapiens |
| 3 | Overall, our findings suggest that cryptotanshinone can sensitize TNF-alpha-induced apoptosis in human myeloid leukemia KBM-5 cells, which appears through ROS-dependent activation of caspase-8 and p38. | cryptotanshinone | caspase 8 | Homo sapiens |