Pub. Date : 2011 Jun
PMID : 21518725
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | B7-H3 silencing increases paclitaxel sensitivity by abrogating Jak2/Stat3 phosphorylation. | Paclitaxel | signal transducer and activator of transcription 3 | Mus musculus |
| 2 | Next, we investigated the mechanisms behind B7-H3-mediated paclitaxel resistance and found that the level of Stat3 Tyr705 phosphorylation was decreased in B7-H3 knockdown cells along with the expression of its direct downstream targets Mcl-1 and survivin. | Paclitaxel | signal transducer and activator of transcription 3 | Mus musculus |
| 3 | Taken together, our data show that in breast cancer cells, B7-H3 induces paclitaxel resistance, at least partially by interfering with Jak2/Stat3 pathway. | Paclitaxel | signal transducer and activator of transcription 3 | Mus musculus |