PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21518725-0 2011 B7-H3 silencing increases paclitaxel sensitivity by abrogating Jak2/Stat3 phosphorylation. Paclitaxel 26-36 signal transducer and activator of transcription 3 Mus musculus 68-73 21518725-5 2011 Next, we investigated the mechanisms behind B7-H3-mediated paclitaxel resistance and found that the level of Stat3 Tyr705 phosphorylation was decreased in B7-H3 knockdown cells along with the expression of its direct downstream targets Mcl-1 and survivin. Paclitaxel 59-69 signal transducer and activator of transcription 3 Mus musculus 109-114 21518725-10 2011 Taken together, our data show that in breast cancer cells, B7-H3 induces paclitaxel resistance, at least partially by interfering with Jak2/Stat3 pathway. Paclitaxel 73-83 signal transducer and activator of transcription 3 Mus musculus 140-145