Pub. Date : 2011 Jul
PMID : 21514634
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We designed a phase II clinical trial evaluating the efficacy and adverse event profile of concomitant topotecan and lapatinib, a small molecule pan-erbB inhibitor that can block BCRP/Pgp efflux of topotecan. | Lapatinib | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | Disruption of erbB signaling and BCRP/Pgp efflux with lapatinib was insufficient for overcoming topotecan resistance, suggesting alternative mechanisms of resistance are involved. | Lapatinib | ATP binding cassette subfamily B member 1 | Homo sapiens |